With the rapid increase in the aging population around the globe, more
Moreover, many diseases
Bone is a dynamic organ maintained by tightly regulated mechanisms
New mechanism for regulating cell division in the bacterial pathogen Klebsiella uncovered
Genetic mouse models have shown the importance of senescent cell clearance in alleviating age-related osteoporosis
new or unusual pain in your thigh, hip or groin; jaw pain, numbness, or swelling; severe joint, bone, or muscle pain; or
Front Cell Dev Biol Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo
inhibits osteoclast farnesyl pyrophosphate synthase enzyme, required in mevalonate (cholesterol pathway) inhibits GTPase formation
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Bisphosphonates inhibit bone resorption by causing osteoclast cell apoptosis, impairing the osteoclast’s resorptive capacity, and preventing osteoclast formation
The main hurdles for stem cell-based therapy for osteoporosis are long-term engraftment and the uncertainty of stem cell fate after transplantation
With the rapid increase in the aging population around the globe, more effective treatments for osteoporosis and osteoporotic fractures are urgently required
The clinical pharmacology (absorption, distribution, metabolism and elimination) will be reviewed, with an emphasis on the relevance to long
Osteoporosis: Mechanism, Molecular Target and Current Status on Drug Development
Osteoporosis, a common chronic metabolic bone disease is associated with considerable morbidity and mortality
Bisphosphonates are highly effective inhibitors of bone resorption that selectively affect osteoclasts