This open-label study was designed to compare the overall survival (OS) of patients randomly assigned to GEM alone or GEM plus capecitabine (GEM-CAP)
In patients with metastatic pancreatic adenocarcinoma, nab-paclitaxel
Takeaway
How is it given? Pancreatic ductal adenocarcinoma (PDA) has become one of the leading
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related deaths
Based on these data, 6 months of adjuvant chemotherapy are currently recommended for patients with resected pancreatic cancer, preferably with combination of gemcitabine and capecitabine, and either with gemcitabine monotherapy or fluorouracil/folinic acid in case of concerns for toxicity or tolerance ( 28 )
9% over 30 minutes
It is frequently associated with other flu-like symptoms such as headache, chills, cough, rhinitis, myalgia, fatigue, sweating and insomnia
Il est donc indispensable d'obtenir des biomarqueurs prédictifs
Capecitabine 1000 mg/m 2 PO BID for 14 d; every 3 wk plus erlotinib 150 mg PO daily continuously [ 19] or
Purpose: Both gemcitabine (GEM) and fluoropyrimidines are valuable treatment for advanced pancreatic cancer
28-Day Schedule: 1000 mg/m2 IV over 30 minutes on Day 1, 8, and 15 in combination with cisplatin 100 mg/m2 IV on Day 1 after gemcitabine administration
Takeaway
Gemcitabine + Capecitabine 20 Days 1,8,15: Gemcitabine 1,000mg/m 2 IV over 30 minutes Days 1-21: Capecitabine 830mg/m 2 orally twice daily
Both gemcitabine (GEM) and fluoropyrimidines are valuable treatment for advanced pancreatic cancer
Gemcitabine, a pyrimidine antimetabolite, is a cornerstone
2016
At this time the major side effect that I am gettin is that I am feeling much better physically and mentally
Substantial antitumor activity has previously been demonstrated with the addition of nab-paclitaxel (Abraxane [Celgene, Summit, NJ]), an albumin-bound formulation of paclitaxel, to gemcitabine in patients with advanced Pancreatic cancer (pancreatic ductal adenocarcinoma [PDAC]) is the fourth-leading cause of cancer death in the United States
Tissues from vehicle and Gemcitabine treated mice were then stained with H&E or by immunohistochemistry for MHC Class 1